Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257458 | 0.88 | EGLN1 (0.67) | EGLN1ALDH1A1 | |
| SCHEMBL30452505 | 0.87 | EGLN1 (0.51) | EGLN1ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL26260056 | 0.87 | EGLN1 (0.51) | EGLN1ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| Formic Acid SCHEMBL30453300 | 0.84 | EGLN1 (0.62) | EGLN1ALDH1A1 | |
| SCHEMBL24257783 | 0.83 | EGLN1 (0.44) | EGLN1ALDH1A1CNR2GPR55HTT | |
| SCHEMBL30453338 | 0.83 | EGLN1 (0.44) | EGLN1ALDH1A1CNR2GPR55HTT | |
| SCHEMBL24257546 | 0.82 | RNASEH1 (0.45) | EGLN1ALDH1A1HPGDCES2CNR2 | |
| SCHEMBL30452522 | 0.82 | RNASEH1 (0.45) | EGLN1ALDH1A1HPGDCES2CNR2 | |
| SCHEMBL26567285 | 0.70 | LMNA (0.55) | ALDH1A1BRD4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL26259639 | 0.69 | EGLN1 (0.52) | EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |