Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058398 | 1.00 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MDM2KDM4E | |
| SCHEMBL3059934 | 1.00 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MDM2KDM4E | |
| SCHEMBL3053992 | 0.91 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MEN1MAPT | |
| SCHEMBL3053952 | 0.91 | DPP4 (0.47) | DPP4SIGMAR1MEN1CYP3A4MAPT | |
| SCHEMBL3050470 | 0.91 | DPP4 (0.47) | DPP4SIGMAR1MEN1CYP3A4MAPT | |
| SCHEMBL3040846 | 0.91 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MEN1MAPT | |
| SCHEMBL8820357 | 0.83 | MAPK1 (0.51) | DPP4SIGMAR1CTRB1MDM2KDM4E | |
| SCHEMBL3706360 | 0.82 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MDM2KDM4E | |
| SCHEMBL3790429 | 0.80 | SIGMAR1 (0.50) | SIGMAR1CYP3A4MAPK1EPHX1ALPI | |
| Hydrochloric Acid SCHEMBL3049777 | 0.79 | SIGMAR1 (0.49) | SIGMAR1CYP3A4MAPK1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222396-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | CYP11B2, CYP11B1, BBC3 | DPP4 139/4885SIGMAR1 264/4885CTRB1 3963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.