Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820357 | 0.83 | MAPK1 (0.51) | DPP4SIGMAR1CTRB1MDM2KDM4E | |
| SCHEMBL3058398 | 0.82 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MMP2MDM2 | |
| SCHEMBL3059934 | 0.82 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MMP2MDM2 | |
| SCHEMBL3045267 | 0.82 | DPP4 (0.47) | DPP4SIGMAR1CTRB1MMP2MDM2 | |
| SCHEMBL3056941 | 0.82 | EPHX2 (0.52) | SIGMAR1CTRB1HPGDSMN1; SMN2PIN1 | |
| SCHEMBL3040918 | 0.82 | EPHX2 (0.52) | SIGMAR1CTRB1HPGDSMN1; SMN2PIN1 | |
| SCHEMBL14628078 | 0.77 | DPP4 (0.47) | DPP4MMP2KDM4EMEN1CYP3A4 | |
| SCHEMBL17944509 | 0.75 | SIGMAR1 (0.51) | SIGMAR1MMP2MDM2KDM4EMEN1 | |
| SCHEMBL7468481 | 0.75 | SIGMAR1 (0.51) | SIGMAR1MMP2MDM2KDM4EMEN1 | |
| SCHEMBL3790431 | 0.74 | SIGMAR1 (0.55) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086366-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2010-08-05 | — | — | WO | disclosed |