Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257718 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL24257690 | 0.89 | CNR1 (0.39) | CNR1PDE10A | |
| SCHEMBL30452359 | 0.89 | CNR1 (0.39) | CNR1PDE10A | |
| SCHEMBL30546879 | 0.88 | HSD17B10 (0.43) | SMN1; SMN2MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL24257819 | 0.88 | HSD17B10 (0.43) | SMN1; SMN2MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL24257777 | 0.84 | MAPT (0.42) | SMN1; SMN2MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL30452976 | 0.82 | NPC1 (0.43) | SMN1; SMN2KDM4ETSHRHTTSTAT3 | |
| SCHEMBL24257684 | 0.82 | NPC1 (0.43) | SMN1; SMN2KDM4ETSHRHTTSTAT3 | |
| SCHEMBL24257768 | 0.81 | SQOR (0.42) | SMN1; SMN2MAPTHSD17B10KDM4EALDH1A1 | |
| Nitrous Acid SCHEMBL29248926 | 0.79 | NPC1 (0.41) | SMN1; SMN2KDM4EHTTSTAT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |