Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257513 | 1.00 | KDM4E (0.38) | KDM4EPDE3BPDE3ALMNAPTGS1 | |
| SCHEMBL24257695 | 0.84 | KDM4E (0.45) | KDM4EHPGDTSHRCYP2C19MAPK1 | |
| SCHEMBL30453176 | 0.84 | KDM4E (0.45) | KDM4EHPGDTSHRCYP2C19MAPK1 | |
| SCHEMBL24257735 | 0.81 | ALOX15 (0.48) | CYP2C19CYP11B1CYP11B2 | |
| SCHEMBL30546870 | 0.80 | KDM4E (0.35) | KDM4EPTGS1HPGDPDE4DALDH1A1 | |
| SCHEMBL24257763 | 0.80 | KDM4E (0.35) | KDM4EPTGS1HPGDPDE4DALDH1A1 | |
| SCHEMBL30454648 | 0.78 | DHFR (0.44) | KDM4ELMNAHPGDALDH1A1NPC1 | |
| SCHEMBL24257698 | 0.78 | DHFR (0.44) | KDM4ELMNAHPGDALDH1A1NPC1 | |
| SCHEMBL24257731 | 0.78 | LRRK2 (0.42) | KDM4ELMNAHPGDTSHRCYP2C19 | |
| SCHEMBL24257776 | 0.77 | KDM4E (0.41) | KDM4ELMNAHPGDTSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |