Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | CCR8 | P51685 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257776 | 1.00 | KDM4E (0.41) | KDM4EPOLBALDH1A1CCR1CCR5 | |
| SCHEMBL30453043 | 0.77 | KDM4E (0.38) | KDM4EPOLBALDH1A1LMNABLM | |
| SCHEMBL3971576 | 0.77 | CCR1 (0.45) | KDM4EPOLBALDH1A1CCR1CCR5 | |
| SCHEMBL24257513 | 0.77 | KDM4E (0.38) | KDM4EPOLBALDH1A1LMNABLM | |
| SCHEMBL30453176 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1CYP1A2KMT2ATSHR | |
| SCHEMBL24257695 | 0.77 | KDM4E (0.45) | KDM4EALDH1A1CYP1A2KMT2ATSHR | |
| SCHEMBL24257723 | 0.76 | SQOR (0.38) | KDM4EPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL30453144 | 0.76 | SQOR (0.38) | KDM4EPOLBALDH1A1LMNAKMT2A | |
| SCHEMBL24257531 | 0.76 | GRM5 (0.52) | KDM4EPOLBALDH1A1GRM5SMN1; SMN2 | |
| SCHEMBL24257623 | 0.74 | DHFR (0.43) | KDM4EPOLBALDH1A1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |