Sugi Predict

Sugi Predict / Compounds / SCHEMBL3045365

SCHEMBL3045365

SCHEMBL3045365

CN(C)c1ccc(-n2nc3ccc([Sn](C)(C)C)cc3n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.49
▸ NPC1 O15118 14/20 0.43
▸ RAB9A P51151 12/20 0.43
▸ MEN1 O00255 10/20 0.43
▸ KMT2A Q03164 10/20 0.43
▸ KDM4E B2RXH2 9/20 0.43
▸ ALDH1A1 P00352 7/20 0.43
▸ MAPT P10636 6/20 0.43
▸ GAA P10253 4/20 0.43
▸ HPGD P15428 4/20 0.43
▸ SMN1; SMN2 Q16637 4/20 0.43
▸ TP53 P04637 2/20 0.43
▸ CASP1 P29466 2/20 0.43
▸ CASP7 P55210 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ NFKB1 P19838 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9704263 0.81 RAB9A (0.57) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3042867 0.79 NPC1 (0.55) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3033496 0.79 ALOX5 (0.50) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL13290970 0.79 NPC1 (0.55) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3042432 0.79 NPC1 (0.55) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL13290986 0.79 ALOX5 (0.50) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3041535 0.79 ALOX5 (0.50) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3048501 0.79 ALOX5 (0.50) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL3038585 0.77 HTT (0.57) ALOX5NPC1RAB9AMEN1KMT2A
SCHEMBL13299383 0.77 ALOX5 (0.50) ALOX5NPC1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100150833-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES MOLECULAR NEUROIMAGING, LLC 2010-06-17 — — US disclosed
US-20100143251-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES MOLECULAR NEUROIMAGING, LLC 2010-06-10 — — US disclosed
US-20100143253-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES MOLECULAR NEUROIMAGING, LLC 2010-06-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100143253-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES APP, BACE1, BACE2 ALOX5 309/4885NPC1 160/4885RAB9A 4657/4885
US-20100150833-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES APP, BACE1, BACE2 ALOX5 309/4885NPC1 160/4885RAB9A 4657/4885
US-20100143251-A1 COMPOUNDS AND AMYLOID PROBES THEREOF FOR THERAPEUTIC AND IMAGING USES APP, BACE1, BACE2 ALOX5 309/4885NPC1 160/4885RAB9A 4657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.