SCHEMBL30453712

SCHEMBL30453712

Nc1ncc(-c2ccc(C(=O)N3CCC[C@@H]3CN3CCCC3)cc2)nc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.79

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 2/20 0.79
MET P08581 13/20 0.74
ATR Q13535 1/20 0.56
HRH3 Q9Y5N1 3/20 0.49
ALK Q9UM73 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL488002 1.00 CSF1R (0.79) CSF1RMETATRHRH3ALK
SCHEMBL30453550 0.92 CSF1R (0.71) CSF1RMETATRHRH3ALK
SCHEMBL488167 0.92 CSF1R (0.71) CSF1RMETATRHRH3ALK
SCHEMBL5488534 0.88 CSF1R (1.00) CSF1RMETATRHRH3ALK
SCHEMBL30453716 0.88 CSF1R (1.00) CSF1RMETATRHRH3ALK
SCHEMBL487740 0.88 CSF1R (1.00) CSF1RMETATRHRH3ALK
SCHEMBL488332 0.87 MET (0.60) CSF1RMETATRHRH3
SCHEMBL488330 0.87 MET (0.60) CSF1RMETATRHRH3
SCHEMBL30452967 0.87 MET (0.60) CSF1RMETATRHRH3
SCHEMBL487984 0.85 MET (1.00) CSF1RMETALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113181362-B Medicament for preventing and/or treating amyotrophic lateral sclerosis 国立大学法人京都大学 2023-06-13 CN disclosed