SCHEMBL30452967

SCHEMBL30452967

Nc1ncc(-c2ccc(C(=O)N3CCC[C@@H]3CN3CCCC3)s2)nc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MET P08581 13/20 0.60
CSF1R P07333 2/20 0.60
ATR Q13535 1/20 0.42
HRH3 Q9Y5N1 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL488332 1.00 MET (0.60) METCSF1RATRHRH3
SCHEMBL488330 1.00 MET (0.60) METCSF1RATRHRH3
SCHEMBL488002 0.87 CSF1R (0.79) METCSF1RATRHRH3
SCHEMBL30453712 0.87 CSF1R (0.79) METCSF1RATRHRH3
SCHEMBL488510 0.86 MET (0.77) METCSF1RHRH3
SCHEMBL30453471 0.86 MET (0.77) METCSF1RHRH3
SCHEMBL30453550 0.85 CSF1R (0.71) METCSF1RATRHRH3
SCHEMBL488167 0.85 CSF1R (0.71) METCSF1RATRHRH3
SCHEMBL30453033 0.83 L3MBTL3 (0.45) METCSF1RATRHRH3
SCHEMBL488785 0.83 L3MBTL3 (0.45) METCSF1RATRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113181362-B Medicament for preventing and/or treating amyotrophic lateral sclerosis 国立大学法人京都大学 2023-06-13 CN disclosed