Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636157 | 1.00 | ATM (0.53) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL29739485 | 0.87 | ALDH1A1 (0.51) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL692339 | 0.85 | ATM (0.55) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL30977610 | 0.85 | ATM (0.55) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL9940716 | 0.84 | ALDH1A1 (0.51) | KMT2AMAPTMEN1RAB9AHTT | |
| SCHEMBL27363244 | 0.83 | ATM (0.46) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL7549531 | 0.83 | TDP1 (0.49) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL17673213 | 0.82 | ATM (0.45) | ATMTDP1KMT2AMEN1RAB9A | |
| SCHEMBL27357985 | 0.82 | ATM (0.51) | ATMTDP1KMT2AMAPTMEN1 | |
| SCHEMBL6584963 | 0.81 | TSHR (0.51) | KMT2AMAPTMEN1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |