Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30977610 | 1.00 | ATM (0.55) | ATMTDP1ALDH3A1MEN1KMT2A | |
| SCHEMBL4636157 | 0.85 | ATM (0.53) | ATMTDP1MEN1KMT2AHTT | |
| SCHEMBL30453750 | 0.85 | ATM (0.53) | ATMTDP1MEN1KMT2AHTT | |
| SCHEMBL9714508 | 0.82 | TDP1 (0.50) | ATMTDP1MEN1KMT2AHTT | |
| SCHEMBL17786752 | 0.82 | ATM (0.62) | ATMTDP1MEN1KMT2AHTT | |
| SCHEMBL6826580 | 0.81 | MAPT (0.52) | ALDH3A1MEN1KMT2AHTTMAPT | |
| SCHEMBL30720021 | 0.81 | GPR35 (0.51) | TDP1ALDH3A1MEN1KMT2AHTT | |
| SCHEMBL26808322 | 0.81 | GPR35 (0.51) | TDP1ALDH3A1MEN1KMT2AHTT | |
| SCHEMBL19554275 | 0.81 | MAPT (0.58) | TDP1ALDH3A1MEN1KMT2AHTT | |
| SCHEMBL6825982 | 0.80 | ALDH3A1 (0.41) | ATMTDP1ALDH3A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349963-B | Sodium channel blockers | 株式会社大熊制药 | 2021-03-30 | — | — | CN | disclosed |
| EP-3375782-B1 | SODIUM CHANNEL BLOCKER | DAE WOONG PHARMA (KR) | 2020-07-29 | — | — | EP | disclosed |
| US-10227338-B2 | Substituted benzenesulfonamides as sodium channel blockers | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2019-03-12 | — | — | US | disclosed |
| US-20180346459-A1 | SODIUM CHANNEL BLOCKER | IN THERAPEUTICS (KR) | 2018-12-06 | — | — | US | disclosed |
| EP-3375782-A1 | SODIUM CHANNEL BLOCKER | Daewoong Pharmaceutical Co., Ltd. (KR) | 2018-09-19 | — | — | EP | disclosed |
| US-20180127423-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE DEUTSCHLAND (DE) | 2018-05-10 | — | — | US | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| US-9701679-B2 | Modulators of 5-HT receptors and methods of use thereof | Abb Vie Deutschland GmbH & Co. KG (DE) | 2017-07-11 | — | — | US | disclosed |
| EP-3150607-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2560973-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2016-11-16 | — | — | EP | disclosed |
| US-8846663-B2 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130310368-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC. | 2013-11-21 | — | — | US | disclosed |
| US-8546377-B2 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8518933-B2 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-06-02 | — | — | US | disclosed |
| US-20100273767-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | US | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227338-B2 | Substituted benzenesulfonamides as sodium channel blockers | HCN4, SCN1B, HCN3 | ATM 4681/4885TDP1 4104/4885ALDH3A1 2111/4885 |
| US-20130310368-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | ATM 4084/4885TDP1 1761/4885ALDH3A1 2088/4885 |
| US-20110130382-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | ATM 4084/4885TDP1 1761/4885ALDH3A1 2088/4885 |
| US-20180127423-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | ATM 4084/4885TDP1 1761/4885ALDH3A1 2088/4885 |
| US-20100273767-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR4, HTR1A, HTR1D | ATM 4084/4885TDP1 1761/4885ALDH3A1 2088/4885 |
| US-20180346459-A1 | SODIUM CHANNEL BLOCKER | SCN5A, SCN2B, SCN1B | ATM 4761/4885TDP1 4623/4885ALDH3A1 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.