SCHEMBL30453946

SCHEMBL30453946

CC(Oc1cc(-c2cccc(C(=O)NC3CCN(C)CC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MET P08581 12/20 0.61
ALK Q9UM73 7/20 0.58
AXL P30530 1/20 0.56
JAK2 O60674 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL488197 1.00 MET (0.61) METALKAXLJAK2
SCHEMBL30453571 0.95 MET (0.55) METALKAXLJAK2
SCHEMBL488572 0.95 MET (0.55) METALKAXLJAK2
SCHEMBL30453512 0.92 MET (0.72) METALKAXLJAK2
SCHEMBL488320 0.92 MET (0.72) METALKAXLJAK2
SCHEMBL487905 0.92 MET (0.54) METALKAXLJAK2
SCHEMBL30453654 0.92 MET (0.54) METALKAXLJAK2
SCHEMBL487858 0.88 MET (0.59) METALKAXL
SCHEMBL30452481 0.88 MET (0.59) METALKAXL
SCHEMBL488450 0.87 MET (0.65) METALKAXLJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113181362-B Medicament for preventing and/or treating amyotrophic lateral sclerosis 国立大学法人京都大学 2023-06-13 CN disclosed