Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933357 | 1.00 | TLR8 (0.38) | TLR8CNR2DHFRCNR1ALOX15 | |
| SCHEMBL5387322 | 0.79 | HTR1B (0.40) | CNR2CNR1MEN1ALDH1A1RAB9A | |
| SCHEMBL15076880 | 0.79 | SLC2A1 (0.34) | TLR8MEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL369244 | 0.76 | CYP2C9 (0.43) | CNR2CNR1MAPTGAATDP1 | |
| SCHEMBL12903863 | 0.76 | DHFR (0.46) | DHFRALOX15DNMT1MEN1ALDH1A1 | |
| SCHEMBL5401288 | 0.74 | KDM4E (0.39) | TLR8CNR2CNR1MEN1ALDH1A1 | |
| SCHEMBL5387664 | 0.73 | KDM4E (0.40) | CNR2CNR1MEN1ALDH1A1RAB9A | |
| SCHEMBL5397688 | 0.73 | KDM4E (0.40) | CNR2CNR1MEN1ALDH1A1RAB9A | |
| SCHEMBL5393198 | 0.73 | KDM4E (0.40) | CNR2CNR1MEN1ALDH1A1RAB9A | |
| SCHEMBL5380785 | 0.73 | KDM4E (0.40) | CNR2CNR1MEN1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444289-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |