Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8388081 | 1.00 | MAOB (0.47) | MAOBMAOAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3838974 | 0.89 | ALDH1A1 (0.54) | MAOBALDH1A1SMN1; SMN2MEN1MITF | |
| SCHEMBL3839157 | 0.89 | ALDH1A1 (0.54) | MAOBALDH1A1SMN1; SMN2MEN1MITF | |
| SCHEMBL3838956 | 0.87 | SMN1; SMN2 (0.58) | MAOBALDH1A1SMN1; SMN2MEN1MITF | |
| SCHEMBL11815584 | 0.86 | SLC6A4 (0.50) | MAOBLMNAEGFR | |
| SCHEMBL30633275 | 0.85 | MAOB (0.55) | MAOBMAOAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3840708 | 0.85 | MAOB (0.55) | MAOBMAOAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16890736 | 0.85 | ALDH1A1 (0.60) | MAOBMAOAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL457828 | 0.85 | MAOB (0.54) | MAOBALDH1A1SMN1; SMN2MEN1MITF | |
| SCHEMBL30020579 | 0.83 | LTA4H (0.57) | MAOBALDH1A1SMN1; SMN2MEN1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447963-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118715015-A | Selective PHD1 inhibitor compounds, compositions and methods of use | 阿克比治疗有限公司 | 2024-09-27 | — | — | CN | disclosed |
| WO-2023111990-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |