Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368325 | 1.00 | KMT2A (0.56) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL5865768 | 0.86 | ALDH1A1 (0.65) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL28459287 | 0.81 | MAPT (0.56) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL13485336 | 0.80 | KIF20A (0.58) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL15286525 | 0.79 | EGFR (0.59) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL8543873 | 0.78 | EGFR (0.64) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL364137 | 0.78 | MAPT (0.58) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL364138 | 0.78 | MAPT (0.58) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL28791207 | 0.78 | KDM4E (0.74) | KMT2AALDH1A1KDM4EPOLBPKM | |
| SCHEMBL29538396 | 0.78 | KDM4E (0.74) | KMT2AALDH1A1KDM4EPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447963-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023111990-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |