Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.54 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28859616 | 0.81 | L3MBTL1 (0.60) | DYRK1ADRD2HTR6HTR2AHTR7 | |
| SCHEMBL5750318 | 0.77 | CDC7 (0.60) | DYRK1AEGFRCDC7CDK5CDK5R1 | |
| SCHEMBL29870510 | 0.77 | CDC7 (0.60) | DYRK1AEGFRCDC7CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL5749287 | 0.76 | CDC7 (0.59) | DYRK1AEGFRCDC7CDK5CDK5R1 | |
| SCHEMBL17683270 | 0.73 | EGFR (0.75) | EGFRADORA2ADRD2HTR2A | |
| SCHEMBL19699869 | 0.72 | EGFR (0.51) | EGFR | |
| SCHEMBL19337232 | 0.72 | CCNB2 (0.44) | DYRK1AEGFRDRD2HTR6HTR2A | |
| SCHEMBL17683100 | 0.71 | EGFR (0.64) | EGFRADORA2ADRD2HTR2A | |
| SCHEMBL29803062 | 0.70 | DYRK1A (0.55) | DYRK1AEGFRCDC7CDK5CDK5R1 | |
| SCHEMBL19337151 | 0.69 | HTR6 (0.44) | DYRK1AEGFRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |