Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.52 |
| ▸ | PRKCI | P41743 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 3/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988049 | 1.00 | NUDT1 (0.52) | NUDT1PRKCIAXLCDK9CDK5 | |
| SCHEMBL2992617 | 0.86 | NUDT1 (0.55) | NUDT1PRKCIAXLCDK9CDK5 | |
| SCHEMBL12605521 | 0.85 | CCNK (0.51) | NUDT1PRKCIAXLCDK9CDK5 | |
| SCHEMBL10124936 | 0.81 | AURKB (0.52) | NUDT1PRKCICDK9CDK5CCNK | |
| SCHEMBL13862497 | 0.79 | MET (0.47) | NUDT1KDRTTBK1TTBK2MET | |
| SCHEMBL29424797 | 0.79 | BRD4 (0.60) | NUDT1PRKCIAXLCDK9CDK5 | |
| SCHEMBL298491 | 0.79 | BRD4 (0.60) | NUDT1PRKCIAXLCDK9CDK5 | |
| SCHEMBL12605417 | 0.77 | IKBKB (0.45) | NUDT1PRKCIAXLBRD4ROCK1 | |
| SCHEMBL858754 | 0.76 | IKBKB (0.57) | NUDT1CDK9CDK5CCNKCDK12 | |
| SCHEMBL3003211 | 0.75 | NUDT1 (0.39) | NUDT1PRKCICDK9CDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444721-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107722-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |