Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Piperonyl Butoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.85 |
| ▸ | TSHR | P16473 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperonyl Butoxide SCHEMBL5586335 | 0.99 | CYP3A4 (0.87) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL7624026 | 0.97 | CYP3A4 (0.85) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL3290495 | 0.93 | CYP3A4 (0.92) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL16105717 | 0.93 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL39695 | 0.93 | CYP3A4 (0.97) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL17765367 | 0.92 | CYP3A4 (0.89) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL6064617 | 0.92 | CYP3A4 (0.84) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL11588274 | 0.92 | CYP3A4 (0.94) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL11589014 | 0.92 | CYP3A4 (0.94) | CYP3A4ALDH1A1TSHRHPGDMEN1 | |
| Piperonyl Butoxide SCHEMBL5490 | 0.92 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11747724-B2 | Organically modified metal oxide nanoparticles, organically modified metal oxide nanoparticles-containing solution, organically modified metal oxide nanoparticles-containing resist composition, and resist pattern forming method | TOKYO OHKA KOGYO CO., LTD. (JP) | 2023-09-05 | — | — | US | disclosed |
| US-20220397823-A1 | ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLE, METHOD FOR PRODUCING SAME, EUV PHOTORESIST MATERIAL, AND METHOD FOR PRODUCING ETCHING MASK | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2022-12-15 | — | — | US | disclosed |
| US-20210191261-A1 | ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES, ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES-CONTAINING SOLUTION, ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES-CONTAINING RESIST COMPOSITION, AND RESIST PATTERN FORMING METHOD | TOKYO OHKA KOGYO CO., LTD. (JP) | 2021-06-24 | — | — | US | disclosed |
| US-20190241475-A1 | CERAMIC COMPOSITION, CUTTING TOOL, AND TOOL FOR FRICTION STIR WELDING | NGK SPARK PLUG CO., LTD. (JP) | 2019-08-08 | — | — | US | disclosed |
| EP-3517517-A1 | CERAMIC COMPOSITION, CUTTING TOOL, AND TOOL FOR FRICTION STIR WELDING USE | NGK Spark Plug Co., Ltd. (JP) | 2019-07-31 | — | — | EP | disclosed |
| EP-2177263-B1 | CATALYST LAYER, MEMBRANE ELECTRODE ASSEMBLY AND FUEL CELL | SHOWA DENKO KK (JP) | 2016-09-07 | — | — | EP | disclosed |
| US-9428823-B2 | Surface-treated steel sheet and method of manufacturing the same | NIPPON STEEL & SUMITOMO METAL CORPORATION (JP) | 2016-08-30 | — | — | US | disclosed |
| US-8268490-B2 | Catalyst layer, membrane electrode assembly and fuel cell | SHOWA DENKO K.K. (JP) | 2012-09-18 | — | — | US | disclosed |
| EP-1978066-B1 | Metal surface treating agents, their preparation, use in treating steel materials, coated steel materials and their production | SHINETSU CHEMICAL CO (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-20100209809-A1 | CATALYST LAYER, MEMBRANE ELECTRODE ASSEMBLY AND FUEL CELL | Showa Denkok K.K. (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-2177263-A1 | CATALYST LAYER, MEMBRANE ELECTRODE ASSEMBLY AND FUEL CELL | Showa Denko K.K. (JP) | 2010-04-21 | — | — | EP | disclosed |
| US-20080248317-A1 | METAL SURFACE TREATING AGENT, SURFACE TREATED STEEL MATERIAL AND TREATING METHOD, AND COATED STEEL MATERIAL AND ITS PRODUCTION METHOD | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2008-10-09 | — | — | US | disclosed |
| EP-1978066-A1 | Metal surface treating agents, their preparation, use in treating steel materials, coated steel materials and their production | Shin-Etsu Chemical Co., Ltd. (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-7052718-B2 | Metal oxide-organopolysiloxane hybrid powder and a method for the preparation thereof and a cosmetic composition therewith | KOSE CORPORATION (JP) | 2006-05-30 | — | — | US | disclosed |
| US-20020172697-A1 | Metal oxide-organopolysiloxane hybrid powder and a method for the preparation thereof and a cosmetic composition therewith | KOSE CORPORATION | 2002-11-21 | — | — | US | disclosed |
| US-5190819-A | Fibers formed of blends of etheric phosphazene polymers and metal oxides and the method of their formation | EASTMAN KODAK COMPANY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5104602-A | METHOD OF FORMING FIBERS OF BLENDS OF ETHERIC PHOSPHAZENE POLYMERS AND METAL OXIDES | EASTMAN KODAK COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0458942-A1 | FIBERS FORMED OF BLENDS OF ETHERIC PHOSPHAZENE POLYMERS AND METAL OXIDES AND THE METHOD OF THEIR FORMATION | EASTMAN KODAK COMPANY (US) | 1991-12-04 | — | — | EP | disclosed |
| US-5034550-A | Reaction of heavy metal tetraalkoxide and heavy metal tricarboxylate, distillation to purify | AKZO N.V. (NL) | 1991-07-23 | — | — | US | disclosed |
| WO-1991009080-A1 | FIBERS FORMED OF BLENDS OF ETHERIC PHOSPHAZENE POLYMERS AND METAL OXIDES AND THE METHOD OF THEIR FORMATION | EASTMAN KODAK COMPANY (US) | 1991-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11747724-B2 | Organically modified metal oxide nanoparticles, organically modified metal oxide nanoparticles-containing solution, organically modified metal oxide nanoparticles-containing resist composition, and resist pattern forming method | MPST, MSN, NCL | CYP3A4 4365/4885ALDH1A1 2129/4885TSHR 3367/4885 |
| US-20020172697-A1 | Metal oxide-organopolysiloxane hybrid powder and a method for the preparation thereof and a cosmetic composition therewith | ZKSCAN2, TYR, FUCA1 | CYP3A4 1443/4885ALDH1A1 1594/4885TSHR 719/4885 |
| US-20210191261-A1 | ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES, ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES-CONTAINING SOLUTION, ORGANICALLY MODIFIED METAL OXIDE NANOPARTICLES-CONTAINING RESIST COMPOSITION, AND RESIST PATTERN FORMING METHOD | MPST, MSN, NCL | CYP3A4 4365/4885ALDH1A1 2129/4885TSHR 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.