Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 13/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30695162 | 0.77 | KMT2A (0.44) | KDM4EJMJD6KMT2AKDM5BKEAP1 | |
| Lithium SCHEMBL31401899 | 0.76 | JMJD6 (0.42) | KDM4EJMJD6KMT2AKDM5BKEAP1 | |
| SCHEMBL18157906 | 0.74 | KMT2A (0.64) | KDM4EJMJD6KMT2AKDM5BKEAP1 | |
| Lithium Ion SCHEMBL31561400 | 0.69 | JMJD6 (0.38) | KDM4EJMJD6KMT2AKDM5BKEAP1 | |
| SCHEMBL15885670 | 0.68 | KEAP1 (0.64) | KDM4EJMJD6KMT2AKEAP1PIK3CD | |
| SCHEMBL208629 | 0.68 | — | — | |
| SCHEMBL30463467 | 0.68 | KDM5B (0.43) | KDM5B | |
| SCHEMBL25253170 | 0.67 | JMJD6 (0.49) | KDM4EJMJD6KMT2AKDM5BKEAP1 | |
| SCHEMBL3324191 | 0.67 | KMT2A (0.60) | KMT2AKEAP1 | |
| SCHEMBL31277599 | 0.67 | JMJD6 (0.49) | KDM4EJMJD6KMT2AKDM5BKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072850-B | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2023-07-21 | — | — | CN | claimed |
| CN-110072850-B | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2023-07-21 | — | — | CN | disclosed |