Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRPK2 | P78362 | 4/20 | 0.45 |
| ▸ | SRPK1 | Q96SB4 | 4/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SRPK3 | Q9UPE1 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051811 | 1.00 | SRPK2 (0.45) | SRPK2SRPK1PTK2CYP1A2CYP2C19 | |
| SCHEMBL29051843 | 0.77 | SRPK3 (0.46) | SRPK2SRPK1PTK2SRPK3AURKA | |
| SCHEMBL29133918 | 0.72 | PTK2 (0.39) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL31273945 | 0.70 | LMNA (0.32) | CYP1A2TP53CYP3A4ALDH1A1JAK2 | |
| SCHEMBL29051675 | 0.69 | PTK2 (0.39) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL12409784 | 0.69 | PTK2 (0.40) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL29783098 | 0.69 | PTK2 (0.40) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL29051782 | 0.68 | PTK2 (0.50) | PTK2AURKAJAK2STK16CDKL5 | |
| SCHEMBL4256517 | 0.68 | HRH3 (0.43) | CYP1A2CYP2C19CYP2D6USP2CYP3A4 | |
| SCHEMBL1995027 | 0.68 | SMN1; SMN2 (0.52) | ALDH1A1KDM4EMAPTKMT2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |