Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482379 | 0.81 | HSD17B13 (0.39) | TDP1GNRHRPLK1KIF11SCD | |
| SCHEMBL30482332 | 0.75 | TDP1 (0.45) | TDP1GNRHRCYP2C9TNKSTNKS2 | |
| SCHEMBL31227314 | 0.73 | TDP1 (0.45) | TDP1GNRHRCYP2C9TNKSTNKS2 | |
| SCHEMBL25431431 | 0.72 | TP53 (0.47) | TDP1CYP2C9LMNATP53MAPT | |
| SCHEMBL30482287 | 0.69 | LMNA (0.46) | TDP1CYP2C9LMNATP53MAPT | |
| SCHEMBL26228669 | 0.69 | HSD17B13 (0.68) | HSD17B13 | |
| SCHEMBL6692824 | 0.64 | AURKA (0.43) | TDP1RORCKIF11CYP2C9SCD | |
| SCHEMBL6780469 | 0.64 | CYP3A4 (0.41) | TDP1RORCKIF11CYP2C9C5AR1 | |
| SCHEMBL6774832 | 0.63 | CD38 (0.44) | TDP1RORCKIF11CYP2C9C5AR1 | |
| SCHEMBL6782082 | 0.63 | RORC (0.42) | TDP1RORCKIF11CYP2C9EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469451-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146897-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2023-08-03 | — | — | WO | disclosed |