Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.42 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9009141 | 1.00 | THRB (0.53) | THRBTGFBR1SCN9AALDH1A1POLB | |
| SCHEMBL27673847 | 0.83 | MAPT (0.67) | THRBTGFBR1ALDH1A1POLBMAPT | |
| SCHEMBL2953474 | 0.82 | MEN1 (0.60) | THRBTGFBR1ALDH1A1POLBMAPT | |
| SCHEMBL17595532 | 0.82 | KMO (0.48) | THRBTGFBR1MAPTTRPV3MEN1 | |
| SCHEMBL29897575 | 0.82 | KMO (0.48) | THRBTGFBR1MAPTTRPV3MEN1 | |
| SCHEMBL13534470 | 0.81 | SCN9A (0.46) | THRBTGFBR1SCN9AALDH1A1POLB | |
| SCHEMBL6484177 | 0.81 | SCN9A (0.43) | THRBTGFBR1SCN9AALDH1A1POLB | |
| SCHEMBL9009001 | 0.81 | NOTUM (0.45) | THRBTGFBR1ALDH1A1POLBMAPT | |
| SCHEMBL4592059 | 0.81 | TRPV3 (0.61) | SCN9ATRPV3 | |
| SCHEMBL31514156 | 0.80 | MAPT (0.43) | THRBTGFBR1MAPTTRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069700-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |