Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250185 | 0.75 | PDE9A (0.35) | GAAKDM4EHPGD | |
| SCHEMBL30305668 | 0.74 | GAA (0.55) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL29638330 | 0.72 | GAA (0.45) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL11411739 | 0.71 | GAA (1.00) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL30484385 | 0.68 | GAA (0.60) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL25149907 | 0.68 | GAA (0.52) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL30364644 | 0.68 | GAA (0.52) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL5093776 | 0.66 | GAA (0.43) | GAAMAPK1KDM4ELDHASMN1; SMN2 | |
| SCHEMBL30613291 | 0.65 | GAA (0.52) | GAAMAPK1CHEK1AURKADAPK3 | |
| SCHEMBL3265613 | 0.64 | CHEK1 (0.67) | GAAMAPK1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142748-B | Pyrazolopyrimidine compound, and preparation method and application thereof | 上海医药集团股份有限公司 | 2023-07-04 | — | — | CN | disclosed |