Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.57 |
| ▸ | TDO2 | P48775 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | CKS1B | P61024 | 2/20 | 0.43 |
| ▸ | SKP1 | P63208 | 2/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25366812 | 1.00 | IDO1 (0.57) | IDO1TDO2KCNH2BACE1CKS1B | |
| SCHEMBL20580826 | 0.86 | IDO1 (0.46) | IDO1TDO2CKS1BSKP1SKP2 | |
| SCHEMBL17738820 | 0.84 | TDO2 (0.56) | IDO1TDO2ALDH1A1MAPT | |
| SCHEMBL31073939 | 0.83 | TDO2 (0.54) | IDO1TDO2 | |
| SCHEMBL3969186 | 0.82 | CYP11B2 (0.47) | IDO1TDO2CKS1BSKP1SKP2 | |
| SCHEMBL30485725 | 0.81 | TDO2 (0.53) | IDO1TDO2ALDH1A1LMNAMAPT | |
| SCHEMBL3673763 | 0.81 | TRPV1 (0.53) | BACE1CKS1BSKP1SKP2KIT | |
| SCHEMBL25365686 | 0.81 | TDO2 (0.53) | IDO1TDO2ALDH1A1LMNAMAPT | |
| SCHEMBL29182786 | 0.81 | BACE1 (0.46) | IDO1TDO2KCNH2BACE1CKS1B | |
| SCHEMBL25365607 | 0.78 | TDO2 (0.58) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479387-A1 | INHIBITORS OF PARG | ARase Therapeutics Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2024173234-A1 | INHIBITORS OF PARG | ARASE THERAPEUTICS INC. (US) | 2024-08-22 | — | — | WO | disclosed |
| WO-2023154913-A1 | INHIBITORS OF PARG | ARASE THERAPEUTICS INC. (US) | 2023-08-17 | — | — | WO | disclosed |