Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | LCAT | P04180 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29039125 | 1.00 | EP300 (0.43) | EP300SCN10AKCNJ1KCNH2CHRNB2 | |
| SCHEMBL31587198 | 0.77 | PIK3CA (0.42) | EP300CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27909230 | 0.76 | CHRNB2 (0.44) | CHRNB2CHRNA4LCATAOC3 | |
| SCHEMBL151047 | 0.76 | MAPT (0.46) | CHRNB2CHRNA4LCATAOC3 | |
| SCHEMBL29039129 | 0.75 | EP300 (0.41) | EP300CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL151160 | 0.74 | MAPT (0.49) | KCNH2CHRNB2CHRNA4GRIN2BLCAT | |
| SCHEMBL148390 | 0.74 | MAPT (0.49) | KCNH2CHRNB2CHRNA4GRIN2BLCAT | |
| SCHEMBL30486004 | 0.73 | RXRA (0.42) | EP300CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2342500 | 0.73 | AOC3 (0.39) | KCNJ1KCNH2CHRNB2CHRNA4OPRM1 | |
| SCHEMBL22914757 | 0.72 | TSHR (0.50) | KCNJ1KCNH2CHRNB2CHRNA4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116462676-A | Multi-condensed ring PRMT5 inhibitor and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-07-21 | — | — | CN | disclosed |