SCHEMBL30488232

SCHEMBL30488232

FC(F)(F)c1cccc(COc2ccc3c(c2)CCC3)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.60
NPC1 O15118 3/20 0.60
RAB9A P51151 3/20 0.60
POLB P06746 2/20 0.60
L3MBTL1 Q9Y468 2/20 0.60
MRGPRX4 Q96LA9 2/20 0.60
GFER P55789 1/20 0.60
PAX8 Q06710 1/20 0.60
KLF5 Q13887 1/20 0.60
SMN1; SMN2 Q16637 3/20 0.56
LMNA P02545 1/20 0.56
GAA P10253 1/20 0.56
HPGD P15428 1/20 0.56
NR4A2 P43354 2/20 0.55
MAPT P10636 2/20 0.55
MAOA P21397 2/20 0.54
HTT P42858 1/20 0.54
RECQL P46063 1/20 0.53
FFAR1 O14842 1/20 0.52
FFAR4 Q5NUL3 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29098003 0.84 MAOB (0.54) MAOBPOLBL3MBTL1NR4A2MAPT
SCHEMBL30198766 0.84 MAOB (0.54) MAOBPOLBL3MBTL1NR4A2MAPT
SCHEMBL25226722 0.80 MAOB (0.69) MAOBPOLBL3MBTL1NR4A2MAPT
SCHEMBL30488283 0.80 MAOB (0.69) MAOBPOLBL3MBTL1NR4A2MAPT
SCHEMBL12472442 0.79 HRH3 (0.72) MAOBNPC1RAB9APOLBL3MBTL1
SCHEMBL11961605 0.79 NPC1 (0.64) MAOBNPC1RAB9APOLBL3MBTL1
SCHEMBL29098060 0.78 NR4A2 (0.56) MAOBNPC1RAB9APOLBL3MBTL1
SCHEMBL30199325 0.78 MAOB (0.53) MAOBPOLBL3MBTL1MRGPRX4NR4A2
SCHEMBL5669711 0.76 MAOB (0.74) MAOBPOLBL3MBTL1MRGPRX4NR4A2
SCHEMBL30299191 0.76 HRH3 (0.72) MAOBNPC1RAB9APOLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4444697-A1 CARBOXYLIC ACID CONTAINING INDANYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CELGENE CORPORATION (US) 2024-10-16 EP disclosed
WO-2023107563-A1 CARBOXYLIC ACID CONTAINING INDANYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CELGENE CORPORATION (US) 2023-06-15 WO disclosed