Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31372241 | 0.89 | HSD17B10 (0.51) | HSD17B10ESR1ADORA3CHRM1ADORA1 | |
| SCHEMBL29440297 | 0.87 | HSD17B10 (0.70) | HSD17B10NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL21107652 | 0.87 | HSD17B10 (0.70) | HSD17B10NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL11853725 | 0.84 | ESR1 (0.69) | HSD17B10ESR1ADORA3CHRM1ADORA1 | |
| SCHEMBL7831372 | 0.82 | NOTUM (0.62) | HSD17B10NOTUMTP53ALDH1A1LMNA | |
| SCHEMBL29040439 | 0.81 | MAPT (0.52) | HSD17B10MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL22075942 | 0.81 | TSHR (0.56) | HSD17B10MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL30369541 | 0.81 | TSHR (0.56) | HSD17B10MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL30457845 | 0.81 | MAPT (0.52) | HSD17B10MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL11844466 | 0.81 | ESR1 (0.74) | HSD17B10ESR1ADORA3CHRM1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130012-A1 | COMPOUNDS FOR MUTANT KRAS PROTEIN DEGRADATION AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2023-07-06 | — | — | WO | disclosed |