Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203840 | 0.83 | NOTUM (0.83) | NOTUMTP53HSD17B10POLBLMNA | |
| SCHEMBL27508585 | 0.83 | NOTUM (0.58) | NOTUMTP53HSD17B10POLBLMNA | |
| SCHEMBL11853725 | 0.83 | ESR1 (0.69) | NOTUMTP53HSD17B10POLBLMNA | |
| SCHEMBL30488348 | 0.82 | HSD17B10 (0.53) | NOTUMTP53HSD17B10POLBLMNA | |
| SCHEMBL11853441 | 0.81 | ALDH1A1 (0.64) | HSD17B10POLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7829951 | 0.80 | NOTUM (0.59) | NOTUMTP53LMNAALDH1A1TSHR | |
| SCHEMBL27691365 | 0.79 | NOTUM (0.72) | NOTUMTP53HSD17B10 | |
| SCHEMBL24011118 | 0.78 | LMNA (0.71) | NOTUMTP53HSD17B10POLBLMNA | |
| SCHEMBL9261533 | 0.77 | ALOX15 (0.56) | TP53HSD17B10POLBLMNASMN1; SMN2 | |
| SCHEMBL14590676 | 0.77 | NOTUM (0.68) | NOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799226-B1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-5972951-A | Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0799226-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019477-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |