Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 7/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.35 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548733 | 1.00 | AXL (0.42) | AXLMKNK1MKNK2TDP1PDPK1 | |
| SCHEMBL9837779 | 0.81 | ALDH1A1 (0.45) | AXLMKNK1MKNK2PDPK1PARP1 | |
| SCHEMBL3544906 | 0.81 | GPR35 (0.39) | AXLMKNK1MKNK2TDP1PDPK1 | |
| SCHEMBL17305955 | 0.81 | PDPK1 (0.40) | AXLMKNK1MKNK2TDP1PDPK1 | |
| SCHEMBL3543082 | 0.77 | POLB (0.37) | TDP1PDPK1PARP1MAPTALDH1A1 | |
| SCHEMBL30598786 | 0.77 | POLB (0.37) | TDP1PDPK1PARP1MAPTALDH1A1 | |
| SCHEMBL9836323 | 0.75 | TDP1 (0.38) | TDP1MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL31484406 | 0.74 | DYRK1A (0.39) | AXLMKNK1MKNK2TDP1MAPT | |
| SCHEMBL28471596 | 0.74 | PDE4A (0.40) | MAPTALDH1A1 | |
| SCHEMBL15655816 | 0.73 | GSK3B (0.48) | TDP1MAPTALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118829451-A | Antibody drug conjugate, pharmaceutical composition and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-10-22 | — | — | CN | disclosed |
| WO-2024041586-A1 | PRODRUG OF JAK KINASE INHIBITOR | 启元生物(杭州)有限公司 | 2024-02-29 | — | — | WO | disclosed |
| CN-117263952-A | Condensed-cyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-111836814-B | Condensed-cyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-116410317-A | Antibody-drug conjugate, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-07-11 | — | — | CN | disclosed |