Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CBS | P35520 | 1/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.43 |
| ▸ | PIM1 | P11309 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30494268 | 0.77 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30494355 | 0.76 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30494101 | 0.75 | MAPT (0.57) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30494209 | 0.75 | DYRK2 (0.40) | DYRK2DYRK3DYRK1ADYRK1BPIM1 | |
| SCHEMBL30494062 | 0.75 | DYRK2 (0.45) | MAPTCYP1A2CYP2C19CYP2C9DYRK2 | |
| SCHEMBL30494396 | 0.75 | DYRK2 (0.40) | DYRK2DYRK3DYRK1ADYRK1BPIM1 | |
| SCHEMBL30363432 | 0.74 | MAPT (0.60) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30396066 | 0.74 | MAPT (0.56) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30363334 | 0.74 | MAPT (0.55) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL30494037 | 0.71 | IDH1 (0.58) | MAPTGAAALDH1A1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |