Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 14/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.83 |
| ▸ | TSHR | P16473 | 2/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | CASP7 | P55210 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaproterenol SCHEMBL6862596 | 1.00 | MEN1 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL41816 | 1.00 | MEN1 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL41815 | 1.00 | MEN1 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL9614523 | 1.00 | MEN1 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL8330430 | 0.94 | BLM (0.88) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL4271 | 0.91 | ADRB2 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL4270 | 0.91 | ADRB2 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL4451598 | 0.91 | ADRB2 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL3694829 | 0.91 | ADRB2 (1.00) | MEN1LMNABLMKMT2AAPEX1 | |
| Metaproterenol SCHEMBL5682997 | 0.90 | ADRB2 (0.96) | MEN1LMNABLMKMT2AAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896161-A | Solid formulations of crystalline compounds | PURDUE RESEARCH FOUNDATION | 2010-11-24 | — | — | CN | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |