Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 15/20 | 0.96 |
| ▸ | TSHR | P16473 | 3/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.96 |
| ▸ | BLM | P54132 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | APEX1 | P27695 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaproterenol SCHEMBL3694829 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL4271 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL4270 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL4451598 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL6141868 | 0.96 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL28921966 | 0.96 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL15391497 | 0.92 | ADRB2 (0.81) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL15392269 | 0.90 | ADRB2 (0.83) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL41816 | 0.90 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1ABLM | |
| Metaproterenol SCHEMBL9614523 | 0.90 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1642574-A2 | Combination of a beta-2 adrenoceptor agonist and an aminosugar and their use for the treatment of immunomodulatory disorders | Astion Development A/S (DK) | 2006-04-05 | — | — | EP | disclosed |
| EP-1496917-B1 | COMBINATION OF A BETA-2 ADRENOCEPTOR AGONISTS AND AN AMINOSUGARS AND THEIR USE FOR THE TREATMENT IMMUNOMODULATORY DISORDERS | ASTION DEV AS (DK) | 2005-12-07 | — | — | EP | disclosed |
| US-20050130935-A1 | Combination of a beta-2-adrenoceptor agonists and an aminosugars and their use for the treatment immunomodulatory disorders | ASTION DEVELOPMENT A/S (DK) | 2005-06-16 | — | — | US | disclosed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |