Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 16/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | APEX1 | P27695 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaproterenol SCHEMBL4270 | 1.00 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL3694829 | 1.00 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL4451598 | 1.00 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL6141868 | 0.98 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL5682997 | 0.98 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL28921966 | 0.98 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL9614523 | 0.91 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL41816 | 0.91 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL15392269 | 0.91 | ADRB2 (0.83) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL3049439 | 0.91 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 27762 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423298-B1 | — | — | None | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-20260132115-A1 | SUBSTITUTED 3-FLUOROBENZENEPROPANOATE COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | TIANJIN GUDUI BIO PHARM CO LTD (CN) | 2026-05-14 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| EP-4699655-A2 | COMPOUNDS | TMEM16A LIMITED (GB) | 2026-02-25 | — | — | EP | claimed |
| US-12545948-B2 | Identification of novel loci in asthma and methods of use thereof for the diagnosis and treatment of asthma | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-02-10 | — | — | US | claimed |
| US-20260027139-A1 | TREATMENT OF SLEEP APNEA WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ALDOSTERONE ANTAGONIST | VIVUS, INC. | 2026-01-29 | — | — | US | claimed |
| US-20260021124-A1 | BUDESONIDE 21-PHOSPHATE SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | GENETIC S P A (IT) | 2026-01-22 | — | — | US | claimed |
| WO-2025265094-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-12-26 | — | — | WO | claimed |
| US-4419364-A | Bronchospasmolytic carbamate derivatives | AKTIEBOLAGET DRACO (SE) | 1983-12-06 | — | — | US | claimed |
| EP-0036426-A4 | NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES. | INTERX RESEARCH CORP (US) | 1983-03-29 | — | — | EP | claimed |
| US-4338455-A | Novel process and intermediates useful in the preparation of sympathomimetic amines | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | claimed |
| EP-0046144-A1 | Therapeutically active derivatives of phenylethanol amines | Aktiebolaget Draco (SE) | 1982-02-17 | — | — | EP | claimed |
| US-4313956-A | Novel sypathomimetic amine prodrugs | INTERX RESEARCH CORP. (US) | 1982-02-02 | — | — | US | claimed |
| EP-0043807-A2 | 1-(Dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates | Aktiebolaget Draco (SE) | 1982-01-13 | — | — | EP | claimed |
| EP-0036426-A1 | NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES. | INTERX RESEARCH CORP (US) | 1981-09-30 | — | — | EP | claimed |
| US-4275219-A | Novel process and intermediates useful in the preparation of sympathomimetic amines | INTERX RESEARCH CORPORATION (US) | 1981-06-23 | — | — | US | claimed |
| WO-1981000849-A1 | NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES | INTERX RESEARCH CORP (US) | 1981-04-02 | — | — | WO | claimed |
| US-4199578-A | TREATMENT OF ASTHMA OR HAY FEVER | FISONS LIMITED (GB) | 1980-04-22 | — | — | US | claimed |