Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 11/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 10/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30459676 | 0.89 | PARP1 (0.50) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30351817 | 0.80 | PARP1 (0.47) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL2333387 | 0.79 | HTR2B (0.49) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30351699 | 0.79 | PARP1 (0.47) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30496990 | 0.77 | PARP1 (0.45) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30352272 | 0.76 | PARP1 (0.44) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30352021 | 0.76 | PARP1 (0.44) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30351630 | 0.75 | PARP1 (0.46) | PARP1HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL30351393 | 0.75 | PARP1 (0.45) | PARP1 | |
| SCHEMBL25211492 | 0.73 | CRBN (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457344-A | Low molecular weight protein degradation agent and application thereof | 凯普托尔治疗学股份有限公司 | 2023-07-18 | — | — | CN | disclosed |