Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20682 | 0.89 | PDE10A (0.34) | PDE10ACCNA2CDK2CDK9CCNA1 | |
| SCHEMBL2679823 | 0.84 | CRHR1 (0.32) | PDE10ACCNA2CDK2CCNA1CRHR1 | |
| SCHEMBL22064 | 0.80 | PDE10A (0.34) | PDE10ACCNA2CDK2CDK9CCNA1 | |
| SCHEMBL30498 | 0.79 | PDE10A (0.32) | PDE10ACRHR1 | |
| SCHEMBL2679434 | 0.79 | CHEK1 (0.34) | PDE10ACCNT1CCNA2CDK2CDK9 | |
| SCHEMBL15026289 | 0.78 | CDK2 (0.38) | PDE10ACCNT1CCNA2CDK2CDK9 | |
| SCHEMBL7885516 | 0.77 | PDE10A (0.33) | PDE10ACCNT1CCNA2CDK2CDK9 | |
| SCHEMBL30714 | 0.77 | PDE10A (0.34) | PDE10ACCNA2CDK2CDK9CCNA1 | |
| SCHEMBL28310 | 0.77 | PDE10A (0.37) | PDE10ACCNT1CCNA2CDK2CDK9 | |
| SCHEMBL20646 | 0.76 | PDE10A (0.36) | PDE10ACCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608669-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |