Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.33 |
| ▸ | BCHE | P06276 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20681022 | 1.00 | ACHE (0.39) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL6231710 | 0.95 | ACHE (0.42) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL19791796 | 0.92 | ACHE (0.46) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL23808911 | 0.90 | ACHE (0.44) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL21810680 | 0.89 | ACHE (0.31) | ACHE | |
| SCHEMBL25404714 | 0.82 | ACHE (0.34) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL30244294 | 0.78 | CASP1 (0.35) | MEN1KMT2AMAPK1ALDH1A1NLRP3 | |
| SCHEMBL18007595 | 0.78 | CASP1 (0.35) | MEN1KMT2AMAPK1ALDH1A1NLRP3 | |
| SCHEMBL18007624 | 0.78 | MEN1 (0.41) | ACHEMEN1KMT2AMAPK1BPTF | |
| SCHEMBL23674334 | 0.76 | MEN1 (0.31) | ACHEMEN1KMT2AMAPK1BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4349820-A2 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | Novartis AG (CH) | 2024-04-10 | — | — | EP | disclosed |
| CN-117209447-A | Compounds and compositions for treating disorders associated with NLRP activity | 诺华股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-117143042-A | Compounds and compositions for treating disorders associated with NLRP activity | 诺华股份有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-111094243-B | Compounds and compositions for treating disorders associated with NLRP activity | 诺华股份有限公司 | 2023-09-05 | — | — | CN | disclosed |