Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25131312 | 1.00 | KDM4E (0.56) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL27006796 | 0.94 | HRH3 (0.54) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL27006787 | 0.91 | ALDH1A1 (0.51) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL14495853 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1SIGMAR1TGFBR1MET | |
| SCHEMBL30499279 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1SIGMAR1TGFBR1MET | |
| SCHEMBL27006913 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1LMNAMAPK1HTT | |
| SCHEMBL30425758 | 0.86 | LMNA (0.43) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL27006819 | 0.85 | TGFBR1 (0.51) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL31103176 | 0.85 | TGFBR1 (0.51) | KDM4EALDH1A1MEN1KMT2ASIGMAR1 | |
| SCHEMBL27006997 | 0.85 | GRM4 (0.52) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201915-A | Pyridazinylamino derivatives as ALK5 inhibitors | 奇斯药制品公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-116096719-A | Pyridazinylamino derivatives as ALK5 inhibitors | 奇斯药制品公司 | 2023-05-09 | — | — | CN | disclosed |