Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | DRD4 | P21917 | 2/20 | 0.67 |
| ▸ | HTR2C | P28335 | 2/20 | 0.67 |
| ▸ | HTR2B | P41595 | 2/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045956 | 0.88 | REV1 (0.70) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL3059849 | 0.86 | REV1 (0.74) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL3059218 | 0.84 | SIGMAR1 (0.66) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL6971135 | 0.81 | SIGMAR1 (0.66) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL3055433 | 0.81 | REV1 (0.70) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL19521553 | 0.81 | SIGMAR1 (1.00) | SIGMAR1TMEM97HTR1ADRD4HTR2C | |
| SCHEMBL10673708 | 0.80 | TMEM97 (0.78) | SIGMAR1TMEM97HTR1ADRD4HTR2C | |
| SCHEMBL3055739 | 0.80 | REV1 (0.72) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL3668878 | 0.80 | REV1 (0.66) | L3MBTL1SIGMAR1TMEM97HTR1ADRD4 | |
| SCHEMBL5131895 | 0.80 | SIGMAR1 (0.58) | SIGMAR1TMEM97HTR1ADRD4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| CN-101677993-A | Compound (I) | STERIX LTD | 2010-03-24 | — | — | CN | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | L3MBTL1 2523/4885SIGMAR1 4163/4885TMEM97 3497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.