Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318334 | 0.82 | GRM5 (0.51) | GRM5MAPKAPK2PIM1PIM3PIM2 | |
| SCHEMBL261816 | 0.81 | GRM5 (0.52) | GRM5MAPKAPK2PIM1PIM3PIM2 | |
| SCHEMBL29844710 | 0.81 | GRM5 (0.52) | GRM5MAPKAPK2PIM1PIM3PIM2 | |
| SCHEMBL14525247 | 0.78 | GRM5 (0.53) | GRM5MAPKAPK2ATRPRKDC | |
| SCHEMBL11922291 | 0.78 | ATR (0.53) | GRM5PIM1PIM3PIM2ATR | |
| SCHEMBL14775168 | 0.76 | MEN1 (0.37) | GRM5MAPKAPK2SIRT6MEN1KMT2A | |
| SCHEMBL30399474 | 0.76 | MEN1 (0.37) | GRM5MAPKAPK2SIRT6MEN1KMT2A | |
| SCHEMBL30937725 | 0.74 | ALDH1A1 (0.38) | GRM5MAPKAPK2SIRT6MEN1KMT2A | |
| SCHEMBL30504276 | 0.74 | GRM5 (0.55) | GRM5MAPKAPK2ATRPRKDC | |
| SCHEMBL11786153 | 0.74 | GRM5 (0.55) | GRM5MAPKAPK2ATRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892601-B | Pyridopyrazolocinnoline compound and preparation method and application thereof | 陕西大美化工科技有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-111892597-B | Quinoxalinyl pyridopyrazine compound and preparation method and application thereof | 山西天宏达安医药科技有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-111925370-B | Pyrazinopyrazoles naphthyridine compound and preparation method and application thereof | 湖北科苑生物药业有限公司 | 2023-07-21 | — | — | CN | claimed |
| CN-111892601-B | Pyridopyrazolocinnoline compound and preparation method and application thereof | 陕西大美化工科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111925370-B | Pyrazinopyrazoles naphthyridine compound and preparation method and application thereof | 湖北科苑生物药业有限公司 | 2023-07-21 | — | — | CN | disclosed |