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Cosyntropin

Cosyntropin

SCHEMBL30506076

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MC2R

The experimentally established mechanism targets of Cosyntropin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ C5AR1 P21730 2/20 0.72
▸ NMBR P28336 2/20 0.65
▸ GRPR P30550 2/20 0.65
▸ MC4R P32245 2/20 0.64
▸ MC5R P33032 2/20 0.64
▸ MC3R P41968 2/20 0.64
▸ MC1R Q01726 2/20 0.64
▸ CRHR1 P34998 1/20 0.61
▸ CRHR2 Q13324 1/20 0.61
▸ CALCR P30988 3/20 0.59
▸ GLP1R P43220 4/20 0.59
▸ F2 P00734 4/20 0.57
▸ GCGR P47871 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cosyntropin SCHEMBL33366 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL29383133 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL29948667 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL27555834 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL522396 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL720535 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL16649201 0.94 C5AR1 (0.74) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL25356191 0.93 C5AR1 (0.73) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL31252906 0.93 C5AR1 (0.73) C5AR1NMBRGRPRMC4RMC5R
Cosyntropin SCHEMBL16649167 0.93 C5AR1 (0.73) C5AR1NMBRGRPRMC4RMC5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4164674-B1 MODULATORS OF TIGHT JUNCTION PERMEABILITY UNIV BATH (GB) 2025-10-22 — — EP disclosed
WO-2025046589-A1 FORMULATIONS COMPRISING A COMBINATION OF ACID-NEUTRALIZING POLYMERIC AND NON-POLYMERIC SUBSTANCES FOR ORAL ADMINISTRATION OF ACTIVE AGENTS ENTERA BIO LTD. (IL) 2025-03-06 — — WO disclosed
EP-4482507-A1 FORMULATIONS COMPRISING ACID-NEUTRALIZING POLYMER FOR ORAL ADMINISTRATION OF ACTIVE AGENTS Entera Bio Ltd. (IL) 2025-01-01 — — EP disclosed
WO-2023161934-A1 FORMULATIONS COMPRISING ACID-NEUTRALIZING POLYMER FOR ORAL ADMINISTRATION OF ACTIVE AGENTS ENTERA BIO LTD. (IL) 2023-08-31 — — WO disclosed
US-20230234987-A1 MODULATORS OF TIGHT JUNCTION PERMEABILITY THE UNIVERSITY OF BATH (GB) 2023-07-27 — — US disclosed
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