Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.66 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.66 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.66 |
| ▸ | ACVR1B | P36896 | 5/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.66 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.66 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.66 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.66 |
| ▸ | BMPR2 | Q13873 | 3/20 | 0.66 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.53 |
| ▸ | FLT1 | P17948 | 6/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30508268 | 0.83 | KDR (0.55) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL5416682 | 0.82 | KDR (0.67) | KDRPRKAB1ACVR1TGFBR1PRKAB2 | |
| SCHEMBL3758736 | 0.79 | MAP4K4 (0.57) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL31060220 | 0.79 | PRKAB1 (1.00) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL6374645 | 0.78 | KMO (0.61) | — | |
| SCHEMBL13126019 | 0.77 | KDR (0.76) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL29042049 | 0.76 | FYN (0.65) | ACVR1TGFBR1BMPR1BACVRL1BMPR1A | |
| SCHEMBL26867136 | 0.75 | ACVR1 (0.74) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL15996329 | 0.75 | ACVR1 (1.00) | KDRPRKAB1ACVR1TGFBR1ACVR1B | |
| SCHEMBL17442229 | 0.74 | ACVR1 (0.73) | KDRPRKAB1ACVR1TGFBR1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |