Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HBB | P68871 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | DPYD | Q12882 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL27747751 | 0.91 | LMNA (0.76) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Adipic Acid SCHEMBL28687655 | 0.88 | LMNA (0.66) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL28206325 | 0.86 | LMNA (0.68) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL28604085 | 0.86 | LMNA (0.58) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL28675239 | 0.84 | TSHR (0.56) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL18529971 | 0.84 | LMNA (0.70) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL20775915 | 0.84 | LMNA (0.70) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Palmitic Acid SCHEMBL8913279 | 0.83 | TSHR (0.54) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Myristic Acid SCHEMBL7613826 | 0.83 | TSHR (0.54) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL21570798 | 0.82 | LMNA (0.61) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023137518-A1 | PLATINUM COMPLEXES | Western Sydney University (AU) | 2023-07-27 | — | — | WO | claimed |
| WO-2023137518-A1 | PLATINUM COMPLEXES | Western Sydney University (AU) | 2023-07-27 | — | — | WO | disclosed |