Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluorouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | THPO | P40225 | 1/20 | 0.76 |
| ▸ | MTOR | P42345 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | HBB | P68871 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | DPYD | Q12882 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL18529971 | 0.92 | LMNA (0.70) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL30516153 | 0.91 | LMNA (0.63) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL27927726 | 0.90 | LMNA (0.86) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL21525858 | 0.88 | LMNA (0.76) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL249289 | 0.87 | MAPT (1.00) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL10017187 | 0.87 | — | — | |
| Fluorouracil SCHEMBL3646 | 0.87 | — | — | |
| Fluorouracil SCHEMBL28206325 | 0.87 | LMNA (0.68) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL2816434 | 0.86 | LMNA (0.79) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 | |
| Fluorouracil SCHEMBL7650203 | 0.85 | MAPT (0.95) | LMNAALDH1A1SMN1; SMN2MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113845483-B | Pink back pteridonic acid and 5-fluorouracil hybrid, preparation method and application thereof | 安徽工业大学 | 2023-08-22 | — | — | CN | claimed |
| CN-116514727-A | 5-fluoro-2, 4-dioxo-3, 4-dihydropyrimidine acetate derivative, preparation method and application thereof | 广西科技大学 | 2023-08-01 | — | — | CN | claimed |
| CN-113845483-A | Dryopteris acid and 5-fluorouracil heterocomplex, preparation method and application thereof | 安徽工业大学 | 2021-12-28 | — | — | CN | claimed |
| CN-101104608-B | Solanesol derivative, preparation and application thereof | UNIV HENAN | 2011-05-04 | — | — | CN | claimed |
| EP-4744663-A2 | SKIN COMPOSITION | Eaderm Co., Ltd. (JP) | 2026-05-20 | — | — | EP | disclosed |
| CN-116514727-B | 5-Fluoro-2, 4-dioxo-3, 4-dihydropyrimidine acetate derivative, preparation method and application thereof | 广西科技大学 | 2026-01-20 | — | — | CN | disclosed |
| CN-116514727-B | 5-Fluoro-2, 4-dioxo-3, 4-dihydropyrimidine acetate derivative, preparation method and application thereof | 广西科技大学 | 2026-01-20 | — | — | CN | disclosed |
| CN-118373974-A | Carbon dioxide-based polycarbonate polyester with double bond functional groups on side groups, and preparation method and application thereof | 武汉理工大学 | 2024-07-23 | — | — | CN | disclosed |
| CN-113845483-B | Pink back pteridonic acid and 5-fluorouracil hybrid, preparation method and application thereof | 安徽工业大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-113845483-B | Pink back pteridonic acid and 5-fluorouracil hybrid, preparation method and application thereof | 安徽工业大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-116514727-A | 5-fluoro-2, 4-dioxo-3, 4-dihydropyrimidine acetate derivative, preparation method and application thereof | 广西科技大学 | 2023-08-01 | — | — | CN | disclosed |
| CN-116514727-A | 5-fluoro-2, 4-dioxo-3, 4-dihydropyrimidine acetate derivative, preparation method and application thereof | 广西科技大学 | 2023-08-01 | — | — | CN | disclosed |
| CN-113845483-A | Dryopteris acid and 5-fluorouracil heterocomplex, preparation method and application thereof | 安徽工业大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-113845483-A | Dryopteris acid and 5-fluorouracil heterocomplex, preparation method and application thereof | 安徽工业大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-109369625-B | Ortho ester 5-fluorouracil prodrug molecule, preparation method thereof, acid-sensitive nanoparticle thereof and application | 安徽大学 | 2020-08-04 | — | — | CN | disclosed |
| CN-107698521-A | A kind of preparation of 5 FU 5 fluorouracil substituted carboxylic acid derivative and purposes | 上海华理生物医药有限公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-103214466-A | Methyl aryl pyrazole fluorouracil compound, preparation method and application | NANJING UNIVERSITY OF TECHNOLOGY | 2013-07-24 | — | — | CN | disclosed |
| CN-103214465-A | Halogen benzyl pyrazole compound containing fluorouracil, preparation method and application | NANJING UNIVERSITY OF TECHNOLOGY | 2013-07-24 | — | — | CN | disclosed |
| CN-101485887-B | 5-fluorouracil-sn2-phosphatidyl choline copolymer and preparation method and application thereof | UNIV PLA 2ND MILITARY MEDICAL | 2011-06-29 | — | — | CN | disclosed |
| CN-101485887-A | 5-fluorouracil-sn2-phosphatidyl choline copolymer as well as preparation method and application thereof | UNIV PLA 2ND MILITARY MEDICAL (CN) | 2009-07-22 | — | — | CN | disclosed |