SCHEMBL30516396

SCHEMBL30516396

[2H]c1c([2H])c([2H])c(-n2ccc(C=O)c2)c(F)c1[2H]

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 2/20 0.42
GRIA2 P42262 2/20 0.42
GRIA3 P42263 2/20 0.42
GRIA4 P48058 2/20 0.42
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30423675 0.76 PTGS1 (0.50) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL31019970 0.73 GRIA1 (0.45) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL30516398 0.72 GRIK1 (0.39) GRIA1GRIA2GRIA3GRIA4
SCHEMBL6052596 0.68 MGLL (0.39) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL17802298 0.66 GRIA1 (0.57) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL5128135 0.66 MGLL (0.43) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL4719825 0.66 IDO1 (0.43) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL1680730 0.63 COMT (0.48) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL30690855 0.63 FAAH (0.46) GRIA1GRIA2GRIA3GRIA4ALDH1A1
SCHEMBL4670630 0.63 GRIA1 (0.39) GRIA1GRIA2GRIA3GRIA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108794449-B Synthetic method of deuterated fumaric acid vorofacian metabolite 广东东阳光药业有限公司 2023-08-04 CN claimed
CN-108794449-B Synthetic method of deuterated fumaric acid vorofacian metabolite 广东东阳光药业有限公司 2023-08-04 CN disclosed