Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24478734 | 1.00 | NPC1 (0.38) | NPC1CASP3RAB9ASMN1; SMN2SENP8 | |
| SCHEMBL24478751 | 0.88 | LDHA (0.42) | NPC1GABRA5P2RX7NR1I2LDHA | |
| SCHEMBL30516696 | 0.88 | LDHA (0.42) | NPC1GABRA5P2RX7NR1I2LDHA | |
| SCHEMBL30516698 | 0.74 | KDM4E (0.41) | ALDH1A1HPGDTSHRCASP1HSD17B10 | |
| SCHEMBL24478766 | 0.74 | KDM4E (0.41) | ALDH1A1HPGDTSHRCASP1HSD17B10 | |
| SCHEMBL16598552 | 0.74 | ALDH1A1 (0.45) | LMNASLC6A4SLC6A3ALDH1A1TSHR | |
| SCHEMBL24525359 | 0.73 | NPC1 (0.51) | NPC1CASP3RAB9ASMN1; SMN2SENP8 | |
| SCHEMBL29654515 | 0.73 | NPC1 (0.51) | NPC1CASP3RAB9ASMN1; SMN2SENP8 | |
| SCHEMBL23460499 | 0.73 | TDP1 (0.50) | NPC1CASP3RAB9ASMN1; SMN2SENP8 | |
| SCHEMBL25486957 | 0.70 | NPC1 (0.41) | NPC1CASP3RAB9ASMN1; SMN2SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116601149-A | Aminoquinazoline derivatives as P2X3 inhibitors | 奇斯药制品公司 | 2023-08-15 | — | — | CN | disclosed |