Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25327490 | 0.79 | HSD17B10 (0.37) | TSHRHSD17B10KDM4EALDH1A1GLA | |
| SCHEMBL25325918 | 0.78 | ALDH1A1 (0.42) | GPR119TSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL25912811 | 0.78 | ALDH1A1 (0.42) | GPR119TSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL4513481 | 0.77 | PDK1 (0.46) | NR1I2GPR119SETD7ALDH1A1CYP1A2 | |
| SCHEMBL14515750 | 0.77 | PDK1 (0.46) | NR1I2GPR119SETD7ALDH1A1CYP1A2 | |
| SCHEMBL25326986 | 0.76 | NR1H2 (0.48) | GPR119NR1H2NR1H3POLB | |
| SCHEMBL25326983 | 0.76 | NR1H2 (0.48) | GPR119NR1H2NR1H3POLB | |
| SCHEMBL25325443 | 0.75 | RIPK1 (0.53) | NR1H2NR1H3 | |
| SCHEMBL25325447 | 0.75 | RIPK1 (0.53) | NR1H2NR1H3 | |
| SCHEMBL271429 | 0.74 | TSHR (0.56) | GPR119NR1H2TSHRSETD7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282749-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2025-09-11 | — | — | US | disclosed |
| EP-4469445-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250282749-A1 | COMPOUNDS AND METHODS OF USE | CYP1B1, CYP2C19, UGT1A1 | NR1I2 159/4885GPR119 1520/4885NR1H2 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.