Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.35 |
| ▸ | PI4KA | P42356 | 10/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526633 | 0.78 | LTA4H (0.44) | PIK3CAPI4KAPI4KBLMNAGAA | |
| SCHEMBL30526832 | 0.78 | ALDH1A1 (0.50) | PIK3CAPI4KAPI4KBPOLBMAPT | |
| SCHEMBL30526740 | 0.78 | MAPT (0.49) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25313007 | 0.77 | DGAT1 (0.39) | DGAT1PIK3CGLMNAPOLBGAA | |
| SCHEMBL31019061 | 0.77 | DGAT1 (0.39) | DGAT1PIK3CGLMNAPOLBGAA | |
| SCHEMBL8143280 | 0.76 | PIK3CD (0.53) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30526576 | 0.75 | EPHX2 (0.53) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30526641 | 0.75 | GAA (0.45) | GAA | |
| SCHEMBL30526666 | 0.74 | NPC1 (0.55) | — | |
| SCHEMBL30526706 | 0.72 | PIK3CD (0.48) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | BEIGENE, LTD. (KY) | 2025-01-23 | — | — | US | disclosed |
| EP-4463456-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BeiGene, Ltd. (KY) | 2024-11-20 | — | — | EP | disclosed |
| CN-118510778-A | Thiazolopyridylamide derivatives as inhibitors of DNA polymerase θ | 百济神州有限公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026766-A1 | Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors | POLQ, POLK, POLI | DGAT1 1109/4885PIK3CA 386/4885PI4KA 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.