Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723790 | 1.00 | TDP1 (0.49) | TDP1LMNASMN1; SMN2HTTCYP3A4 | |
| SCHEMBL3114727 | 0.89 | HTT (0.50) | TDP1LMNASMN1; SMN2HTTCYP3A4 | |
| SCHEMBL20303461 | 0.82 | TDP1 (0.53) | TDP1LMNASMN1; SMN2HTTCYP3A4 | |
| SCHEMBL15304198 | 0.79 | ACHE (0.43) | TDP1LMNASMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL613715 | 0.78 | CYP3A4 (0.47) | TDP1LMNAHTTCYP3A4MEN1 | |
| SCHEMBL5892425 | 0.77 | ALDH1A1 (0.39) | TDP1LMNACYP3A4CYP2C19MEN1 | |
| SCHEMBL13639298 | 0.77 | SNCA (0.33) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL17940744 | 0.73 | CA1 (0.40) | TDP1HTTMAPTALDH1A1CA12 | |
| SCHEMBL20312474 | 0.73 | HSD17B10 (0.42) | TDP1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13043980 | 0.71 | TSHR (0.47) | TDP1LMNASMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463456-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BeiGene, Ltd. (KY) | 2024-11-20 | — | — | EP | disclosed |
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |