Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25306038 | 1.00 | CHEK1 (0.34) | CHEK1AURKAEGFRCYP11B1CYP11B2 | |
| SCHEMBL25259343 | 0.73 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL31250340 | 0.72 | HTR2A (0.39) | EGFRCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25305763 | 0.72 | HTR2A (0.39) | EGFRCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL31152732 | 0.69 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL26126648 | 0.67 | CYP2D6 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL31232891 | 0.67 | CYP2D6 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL24861474 | 0.65 | CHEK1 (0.38) | CHEK1AURKAEGFRCYP11B1CYP11B2 | |
| SCHEMBL7895339 | 0.64 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL4880551 | 0.63 | CHEK1 (0.41) | CHEK1AURKAEGFRCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463459-A1 | STAT MODULATORS AND USES THEREOF | Recludix Pharma, Inc. (US) | 2024-11-20 | — | — | EP | disclosed |
| CN-118804917-A | STAT modulators and uses thereof | 瑞克鲁迪克斯制药股份有限公司 | 2024-10-18 | — | — | CN | disclosed |
| WO-2023133336-A1 | STAT MODULATORS AND USES THEREOF | RECLUDIX PHARMA, INC. (US) | 2023-07-13 | — | — | WO | disclosed |