Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | USP7 | Q93009 | 3/20 | 0.44 |
| ▸ | USP47 | Q96K76 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2873852 | 1.00 | TDP1 (0.50) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL2873855 | 1.00 | TDP1 (0.50) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL13131631 | 0.86 | MAPT (0.46) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL25170030 | 0.82 | TDP1 (0.53) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL3503761 | 0.82 | TDP1 (0.53) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL2071280 | 0.80 | TDP1 (0.64) | TDP1L3MBTL1TSHRFEN1MAPT | |
| SCHEMBL7764416 | 0.80 | TDP1 (0.50) | TDP1L3MBTL1USP7USP47TSHR | |
| Hydrochloric Acid SCHEMBL11156407 | 0.79 | TDP1 (0.62) | TDP1L3MBTL1TSHRFEN1MAPT | |
| SCHEMBL23302690 | 0.78 | TDP1 (0.47) | TDP1L3MBTL1USP7USP47TSHR | |
| SCHEMBL793527 | 0.77 | ALDH1A1 (0.61) | TDP1L3MBTL1TSHRMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | TDP1 1632/4885L3MBTL1 1975/4885USP7 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.